Isolated DC-DC chargers feature galvanic isolation, meaning they electrically and physically separate the input and output circuits. This isolation is typically achieved using a transformer. Effectively reduce noises breaking ground loops, improves electrical safety and shift reference voltage if needed in the application.

Non-isolated DC-DC chargers lack galvanic isolation, and they share a common ground connection (negative) between the input and output voltages. Higher efficiency and are a more cost-effective solution.

Choosing between isolated and non-isolated DC-DC chargers depends on your specific project requirements. If safety, ground loop isolation, or reference voltage shifting is critical, isolated chargers are the way to go. On the other hand, if cost savings, space constraints, or energy efficiency are your primary concerns, non-isolated chargers offer a practical solution.